Abstract
IN accord with H. B. F. Dixon and M. P. Stack-Dunne1, who studied the behaviour of adrenocorticotropic hormone on a chromatographic column of a carboxy-type ion-exchange resin, we have found that the crude substance (I) prepared, according to the method of Lyons2, from dry hypophysis powder previously desiccated by acetone is different from the crude preparation (II) extracted from fresh hypophysis by the same acid–acetone solvent. These preparations show different behaviour when we attempt their purification.
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References
Dixon, H. B. F., and Stack-Dunne, M. P., Biochem. J., 61, 483 (1955).
Lyons, W. R., Proc. Soc. Exp. Biol., N.Y., 35, 645 (1937).
Astwood, E. B., Raben, M. S., Payne, R. W., and Grady, A. B., J. Amer. Chem. Soc., 73, 2969 (1951).
van Dyke, H. B., Chow, B. F., Greep, R. O., and Rothen, A., J. Pharmacol. Exp. Therap., 74, 190 (1942).
Hegyeli, E., Experientia, 12, 222 (1956).
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HEGYELI, E., MOLNAR, I. Preparation of Adrenocorticotropic Hormone from Fresh and Desiccated Hypophysis. Nature 179, 736–737 (1957). https://doi.org/10.1038/179736a0
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DOI: https://doi.org/10.1038/179736a0
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