Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

In vitro Effect of Growth Hormone on the Glucose Uptake of Isolated Rat Diaphragm

Nature volume 179, pages 472–473 (1957)Cite this article

Abstract

THERE is a disagreement in the literature concerning the in vitro action of growth hormone on the glucose uptake of the isolated diaphragm of the normal rat. Ottaway1,2 has reported that growth hormone added to the Stadie–Zapp buffer3 will stimulate the glucose uptake of the isolated rat diaphragm. Park et al. 4 using Krebs–Henseleit bicarbonate buffer5 and Randle and Young6 using Gey and Gey buffer7, which is qualitatively similar to the Krebs–Henseleit buffer, have reported that growth hormone in vitro is without effect on the glucose uptake of the isolated diaphragm from normal rats. It was of interest, therefore, to compare the effect of growth hormone added in vitro on the glucose uptake of the isolated rat diaphragm incubated either in Stadie–Zapp buffer3 or in Gey and Gey buffer7.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Ottaway, J. H., Biochim. Biophys. Acta., 11, 443 (1953).

    Article  CAS  Google Scholar 

  2. Ottaway, J. H., and Bulbrook, R. D., J. Endocrinol., 12, 50 (1955).

    Article  CAS  Google Scholar 

  3. Stadie, W. C., and Zapp, J. A., J. Biol. Chem., 170, 55 (1947).

    CAS  Google Scholar 

  4. Park, C. R., “Phosphorus Metabolism”, 2, 634, Edit. McElroy, W. D., and Glass, B. (Johns Hopkins Press, 1952).

    Google Scholar 

  5. Krebs, H. A., and Henseleit, K., Z. physiol. Chem., 210, 33 (1932).

    Article  CAS  Google Scholar 

  6. Randle, P. J., and Young, F. G., J. Endocrinol., 13, 335 (1956).

    Article  CAS  Google Scholar 

  7. Gey, G. O., and Gey, M. K., Amer. J. Cancer, 27, 45 (1936).

    Article  Google Scholar 

  8. Somogyi, M., J. Biol. Chem., 195, 19 (1952).

    CAS  Google Scholar 

Download references

Author information

Author notes

  1. J. E. WHITNEY

    Present address: Medical Centre, University of Arkansas, Little Rock, U.S.A.

  2. J. E. WHITNEY: Fellow in Cancer Research of the American Cancer Society recommended by the Committee on Growth, National Research Council

Authors and Affiliations

  1. Department of Biochemistry, University of Cambridge,

    P. J. RANDLE & J. E. WHITNEY

Authors
  1. P. J. RANDLE
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. E. WHITNEY
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

RANDLE, P., WHITNEY, J. In vitro Effect of Growth Hormone on the Glucose Uptake of Isolated Rat Diaphragm. Nature 179, 472–473 (1957). https://doi.org/10.1038/179472b0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/179472b0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing