Abstract
AMINOMALONIC acid was first described by Baeyer1 in 1864, who found that heat treatment converted the amino-acid smoothly into glycine. Knoop2 suggested the intermediary formation of aminomalonic acid in the biological formation of glycine from serine. But Haas3 could not find evidence that it is a precursor of glycine in the rabbit, either in experiments on the whole organism, or in the isolated liver, or with liver homogenate. Shemin4 has claimed to have excluded aminomalonic acid as an intermediate in the metabolic change of serine to glycine from results obtained by isotopic studies. However, this view was criticized by Ogston5.
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References
Baeyer, A., Ann. der Chem., 131, 291 (1864).
Knoop, F., Z. physiol. Chem., 89, 151 (1914); ibid., 170, 186 (1927).
Haas, G., Biochem. Z., 76, 76 (1916).
Shemin, D., J. Biol. Chem., 162, 297 (1946).
Ogston, A. G., Nature, 162, 963 (1948).
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SHIMURA, K., NAGAYAMA, H. & KIKUCHI, A. Aminomalonic Acid Decarboxylase : a New Enzyme. Nature 177, 935–936 (1956). https://doi.org/10.1038/177935b0
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DOI: https://doi.org/10.1038/177935b0
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