Abstract
Nicol and Snell1 showed that cortisone depresses the phagocytic activity of the reticulo-endothelial system during the first two weeks of treatment, and that if the cortisone injections are continued the reticulo-endothelial system apparently recovers during the third and fourth weeks. Nicol and Bilbey2 reported that cortisone also produces changes in the blood. They showed that when 10 mgm. of cortisone is given daily intramuscularly for one or two weeks, the total leucocyte count falls, due to reduction in the number of lymphocytes and polymorphs; but if the cortisone is continued for three or four weeks the total leucocyte count returns to normal, due to increase in the number of polymorphs, although the lymphocyte count remains low.
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References
Nicol, T., and Snell, R. S., Nature, 174, 554 (1954); [177, 430 (1956)].
Nicol, T., and Bilbey, D., Nature, [177, 524 (1956)].
Bjørneboe, M., Fischel, E. E., and Stoerk, H., J. Exp. Med., 93, 37 (1951).
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SNELL, R., NICOL, T. Effect of Cortisone on the Serum Gamma-Globulin. Nature 177, 578 (1956). https://doi.org/10.1038/177578a0
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DOI: https://doi.org/10.1038/177578a0
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