Abstract
IN this communication evidence is presented that catalase is required in one of the steps of tyrosine metabolism, namely, the conversion of p-hydroxy-phenylpyruvic acid to homogentisic acid. This oxidation requires two protein fractions which have been separated and partially purified from dog liver by treatment with organic solvents followed by fractionation with ammonium sulphate1. Fraction A is precipitated by 0.40–0.55 saturated ammonium sulphate; fraction B by 0.60–0.75 saturated ammonium sulphate.
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References
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LA DU, B., ZANNONI, V. A Requirement for Catalase in Tyrosine Metabolism : the Oxidation of p-Hydroxy-phenylpyruvic Acid to Homogentisic Acid. Nature 177, 574–575 (1956). https://doi.org/10.1038/177574b0
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DOI: https://doi.org/10.1038/177574b0
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