Abstract
CLAYSON1 has suggested that aromatic amines are carcinogenic by virtue of their transformation in the animal body into orthohydroxyamines. Walpole, Williams and Roberts2 have shown that 4-amino-diphenyl is a potent inducer of bladder tumours in the dog, and Spitz (quoted by Walpole et al.2) has obtained bladder tumours in this species with benzidine. The purpose of this communication is to show that these aromatic amines are in fact converted into orthohydroxyamine derivatives by the dog.
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References
Clayson, D. B., Ann. Rep. Brit. Emp. Cancer Campaign, 29, 148 (1951); Brit. J. Cancer, 7, 460 (1953).
Walpole, A. L., Williams, M. H. C., and Roberts, D. C., Brit. J. Indust. Med., 11, 105 (1954).
Boyland, E., and Sims, P., J. Chem. Soc., 980 (1954).
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BRADSHAW, L., CLAYSON, D. Metabolism of Two Aromatic Amines in the Dog. Nature 176, 974–975 (1955). https://doi.org/10.1038/176974a0
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DOI: https://doi.org/10.1038/176974a0
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