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Fractionation of the Deoxyribonucleic Acid of T2r Bacteriophage

Abstract

A NUMBER of investigations indicate that the deoxyribonucleic acid (DNA) of T2 bacteriophage plays a major part during the infection of its bacterial host and in the maintenance of genetic continuity during the multiplication process1. Recent work2 has demonstrated the inhomogeneity of deoxyribonucleic acid from various sources with respect to the content of the purine and pyrimidine bases and the ease of dissociation from complexes with basic proteins. This communication describes results obtained by applying a chromatographic fractionation procedure based on the latter property to the deoxyribonucleic acid of T2r bacteriophage.

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References

  1. Hershey, A. D., and Chase, M., J. Gen. Physiol., 36, 39 (1952). Hershey, A. D., Cold Spring Harbor Symp. Quant. Biol., 18, 135 (1953). Hershey, A. D., Dixon, J., and Chase, M., J. Gen. Physiol., 36, 777 (1953). Hershey, A. D., Virology, 1, 108 (1955).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Brown, G. L., and Watson, M., Nature, 172, 339 (1953). Chargaff, E., Crampton, C. F., and Lipshitz, R., Nature, 172, 289 (1953). Elson, D., Gustafson, T., and Chargaff, E., J. Biol. Chem., 209, 285 (1955).

    Article  ADS  CAS  PubMed  Google Scholar 

  3. Herriott, R. M., and Barlow, J. L., J. Gen. Physiol., 36, 17 (1952)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Crampton, C. F., Lipshitz, R., and Chargaff, E., J. Biol. Chem., 206, 499 (1954).

    CAS  PubMed  Google Scholar 

  5. Hoffpauir, C. L., and Guthrie, J. D., Textile Res. J., 20, 617 (1950).

    Article  CAS  Google Scholar 

  6. Campbell, D. H., Leuscher, E., and Lerman, L. S., Proc. U.S. Nat. Acad. Sci., 37, 575 (1951).

    Article  ADS  CAS  Google Scholar 

  7. Anderson, T. F., Ann. Inst. Pasteur, 84, 5 (1953).

    CAS  Google Scholar 

  8. Wyatt, G. R., and Cohen, S. W., Biochem. J., 55, 774 (1953).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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BROWN, G., MARTIN, A. Fractionation of the Deoxyribonucleic Acid of T2r Bacteriophage. Nature 176, 971–972 (1955). https://doi.org/10.1038/176971a0

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