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Influence of Osmotic Pressure on the Polyamine Requirement of Neisseria perflava and Pasteurella tularensis for Growth in Defined Media

Nature volume 176, pages 933–934 (1955)Cite this article

Abstract

THE discovery by Herbst and Snell1 that putrescine or related di- and poly-amines constitute an essential growth requirement for Haemophilus parainfluenzae assigned for the first time a biological function to these substances, known to be of wide occurrence in Nature2. Afterwards, putrescine was recognized as an indispensable growth factor for Neisseria perflava 3 and a stimulatory agent for Pasteurella tularensis 4. The aim of the present communication is to describe an interrelationship observed between the tonicity of the medium and the polyamine requirement. This observation seems to throw light on the mechanism of the growth-promoting action of these compounds.

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References

  1. Herbst, E. J., and Snell, E. E., J. Biol. Chem., 181, 47 (1949).

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  2. Guggenheim, M., “Die biogenen Amine” (3rd edit., Basel, 1940).

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  3. Martin, J. H., Pelczar, jun., M. J., and Hansen, P. A., Science, 116, 483 (1952).

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Authors and Affiliations

  1. Department of Biochemistry, The Hebrew University-Hadassah Medical School, Jerusalem

    J. MAGER

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  1. J. MAGER
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MAGER, J. Influence of Osmotic Pressure on the Polyamine Requirement of Neisseria perflava and Pasteurella tularensis for Growth in Defined Media. Nature 176, 933–934 (1955). https://doi.org/10.1038/176933a0

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