Long-term Transplants of Infantile Rat Pituitaries cultivated in vitro and grafted into the Anterior Eye Chamber of Young Cats

Abstract

IN a previous communication in Nature ¹, we have reported that successful grafts of the anterior rat pituitary have been obtained when glands cultivated in vitro were transplanted into the anterior eye chamber of very young cats. Following the same line of work, we have transplanted rat ovaries and testes, both normal and cultivated in vitro, under the kidney capsule of adult cats and observed a phenomenon which, so far as we know, has not been recorded in biological literature. A few days following the transplantation, at the site of grafting a ‘tumour’ was formed which when sectioned and stained was found to be composed almost exclusively of lymphocytes that had migrated into this region. Remnants of the grafted tissue, surrounded by lymphocytes, were also preisent, some in advanced stages of degeneration.