Abstract
BETWEEN the cell bodies, the neuroglial fibres, and the nerve processes of the central nervous system, there are spaces. These spaces are filled with a ground substance of a carbohydrate – protein nature, revealed by staining with the periodic acid – Schiff reagents1. The concept of a blood – brain barrier was formulated when it was discovered that intravenously administered trypan blue stains extensively other organs of the body, but does not stain the brain2. Numerous subsequent investigations have demonstrated that trypan blue, administered intravenously or intraperitoneaily, is a valid test substance for the presence or absence of a blood – brain barrier3.
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References
Hess, A., J. Comp. Neurol., 98, 69 (1953).
Goldmann, E. E., “Vitalfärbung am Zentralnervensystem” (Georg Reimer, Berlin, 1913).
King, L. S., Arch. Neurol. and Psychiat., 41, 51 (1939).
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Hess, A., J. Comp. Neurol. (in the press).
Macklin, C. G., and Macklin, M. T., Arch. Neurol. and Psychiat., 3, 353 (1920).
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HESS, A. Relation of the Ground Substance of the Central Nervous System to the Blood - Brain Barrier. Nature 175, 387–388 (1955). https://doi.org/10.1038/175387a0
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DOI: https://doi.org/10.1038/175387a0
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