Abstract
IT has been reported1 that hide collagen and other proteins dissolve in anhydrous hydrogen fluoride. The fact that some proteins, like insulin, were recovered with up to 80 per cent of their initial biological activity, after solution in this solvent, suggested that collagen might dissolve without denaturation. The ability to reconstitute characteristic collagen fibrils from solution was used as the criterion of the absence of denaturation.
Similar content being viewed by others
Article PDF
References
Katz, J. J., Nature, 173, 265 (1954).
Highberger, J. H., Gross, J., and Schmitt, F. O., Proc. U.S. Nat. Acad. Sci., 37, 286 (1954).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DREIKORN, R., O'GORMAN, V. Anhydrous Hydrogen Fluoride as a Collagen Solvent. Nature 175, 385 (1955). https://doi.org/10.1038/175385a0
Issue Date:
DOI: https://doi.org/10.1038/175385a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.