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Hæmolytic Anæmia produced Experimentally in the Guinea Pig by T-transformation of the Erythrocytes in vivo with Purified Concentrated Enzyme

Abstract

DURING the continuation of work aimed at explaining the development and possible significance of the Thomsen phenomenon1 in vivo (so-called poly-agglutinability), it proved practicable to produce hæmolytic anæmia in guinea pigs by T-transformation of their erythrocytes in vivo. The term ‘T-transformation’ applies to the production of the specific receptor-T in erythrocytes through the activity of an enzyme formed by various bacterial species1.

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References

  1. Friedenreich, V., “The Thomsen Hemagglutination Phenomenon”, dissert. (Levin and Munksgaard, 1930).

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  2. Ejby-Poulsen, P., Nature, 173, 82 (1954).

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  3. Burnet, F. M., and Anderson, S. G., Aust. J. Exp. Biol. Med. Sci., 25, 213 (1947).

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EJBY-POULSEN, P. Hæmolytic Anæmia produced Experimentally in the Guinea Pig by T-transformation of the Erythrocytes in vivo with Purified Concentrated Enzyme. Nature 174, 929–930 (1954). https://doi.org/10.1038/174929a0

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  • DOI: https://doi.org/10.1038/174929a0

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