Abstract
IN experiments dealing with the connexion between the adrenocorticotrophic hormone (ACTH) and intermedin, we have tried to protect the hormone from inactivating oxidation by the addition of substances with a low redox potential. Among others, ascorbic acid (Merck) has been used, as it is well known that it protects for several hours from oxidation, for example, highly diluted solutions of sympathins. But contrary to expectation, it was found that after the incubation of an adrenocorticotrophic hormone preparation of Schering in a Ringer solution containing 10 mgm./100 gm. ascorbic acid at + 4° C. overnight, its originald chromatophore-expanding activity was found to be reduced to 2 per cent.
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HOLZBAUER, M., RIGLER, R. Inactivation of the Chromatophore-expanding Activity of Pituitary Extracts by Ascorbic Acid. Nature 174, 877 (1954). https://doi.org/10.1038/174877a0
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DOI: https://doi.org/10.1038/174877a0
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