Abstract
SANDLER1 claimed that the protective factor against benzene poisoning found in yellow bone marrow is batyl alcohol or one of its esters. Since batyl alcohol is found in those organs which are said to contain a humoral factor that protects animals against the acute phase of irradiation injury2, the following experiments were carried out. Sixty adult white male mice of an inbred strain (16 years) were irradiated with a therapeutic X-ray machine, 165 kV., 15 m.amp., filters 0.5 mm. copper + 1 mm. aluminium, target distance 60 cm., irradiation time 25 min., total dose 750 r. (air). Two hours after the end of the irradiation, thirty animals chosen at random were given 0.1 ml. of peanut oil subcutaneously, the others the same volume of peanut oil containing 2.5 mgm. dl-batyl alcohol per ml. These injections were repeated every second day until 1.75 mgm. of dl-batyl alcohol or a corresponding amount of the solvent had been administered to the animals. The 30-day letbality for the animals treated with batyl alcohol was seventeen out of thirty and for the controls twenty-six out of thirty. The difference is statistically significant (P < 0.01).
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References
Sandler, O. E., Acta Medica Scand., Supp. 225 (1949).
Lorenz, E., and Congdon, Ch. C., “Annual Review of Medicine”, 5, 323 (1954).
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EDLUND, T. Protective Effect of d,l-α-Octadecylglycerol-ether in Mice given Total Body X-Irradiation. Nature 174, 1102 (1954). https://doi.org/10.1038/1741102a0
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DOI: https://doi.org/10.1038/1741102a0
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