Effect of Hyaluronidase on the Mortality from Experimental Burns

Abstract

IN treating secondary shock, the intravenous route of fluid administration may not be possible under certain conditions, as, for example, in small infants or in the event of a catastrophe when sufficient trained personnel are not available. In lieu of the intravenous route, the interstitial administration of fluids containing hyaluronidase to assist assimilation has been used clinically in recent years¹. With the addition of this enzyme to break down hyaluronic acid, the fluid spreads more rapidly throughout the connective tissue, thereby entering the capillaries more rapidly, with a consequent increase in the effectiveness of the shock therapy.