Abstract
IT has been shown by Hechter1 that, in the living animal, the spreading effect of hyaluronidase depends upon several factors. Inhibition of this effect such as has been reported to result from the administration of salicylates2 may not therefore be due, necessarily, to depression of enzyme activity. The effect of hyaluronidase upon the permeability of connective tissue may be demonstrated on pieces of isolated fascia in vitro3. This method may be expected to give an indication of the action of hyaluronidase alone, since other factors which complicate the phenomenon of spread in vivo are excluded.
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References
Hechter, O., Ann. N.Y. Acad. Sci., 52, 1028 (1950).
Pelloja, M., Lancet, 233 (1952).
Day, T. D., J. Physiol., 117, 1 (1952).
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DAY, T. Hyaluronidase and Salicylates. Nature 171, 268–269 (1953). https://doi.org/10.1038/171268a0
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DOI: https://doi.org/10.1038/171268a0
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