Abstract
Aspergillus infections in pediatric bone marrow transplant (BMT) patients are usually fatal. We began the use of a prophylactic nasal spray of amphotericin in 1990. This nasal spray was provided in addition to low-dose intravenous amphotericin. During the time of this study, the number of fatal cases of aspergillus in the pediatric BMT population was reduced significantly from 13.8% to 1.8% (Pā<ā0.0025) thereby suggesting that the use of nasal amphotericin in this population helps to prevent fatal aspergillus infections. the lack of significant side-effects and the ease of administration make this a very helpful preventive measure in the supportive care of pediatric bone marrow transplant patients.
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Trigg, M., Morgan, D., Burns, T. et al. Successful program to prevent aspergillus infections in children undergoing marrow transplantation: use of nasal amphotericin. Bone Marrow Transplant 19, 43ā47 (1997). https://doi.org/10.1038/sj.bmt.1700618
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DOI: https://doi.org/10.1038/sj.bmt.1700618
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