Abstract
THE regulation of blood flow in the peripheral tissues is still an unsolved problem in the physiology of the circulation. The cause of reactive hyperæmia following the release of a previously clamped artery has been attributed to an accumulation of specific vasodilator substances (as acetylcholine, histamine, etc.), or to metabolites with vasodilator effects (especially lactate and pH changes). Rein1 regards the co-operation of both factors as the clue to a proper blood supply.
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ISSEKUTZ, B., LICHTNECKERT, I., NÉMETH-GÁSPÁR, Z. et al. Tissue Metabolism and Peripheral Circulation. Nature 167, 988–989 (1951). https://doi.org/10.1038/167988b0
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DOI: https://doi.org/10.1038/167988b0
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