Abstract
THE effects of anaerobic conditions on mammalian epidermis were first studied by Medawar1, who developed an elegant technique for showing that this tissue can survive by anaerobic glycolysis alone, but that cell movement and division depend on “respiratory activity in the narrow sense”. These conclusions, which apply to the rabbit, have now been confirmed and elaborated in the case of the mouse. A technique has been devised, using standard Warburg equipment, for the maintenance of ear epidermis from adult male mice in a phosphate-buffered saline with added glucose.
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References
Medawar, P. B., Quart. J. Micr. Sci., 88, 27 (1947).
Bullough, W. S., J. Exp. Biol., 26, 83 (1949).
Bullough, W. S., J. Endocrinol., 6, 350 (1950).
Bullough, W. S., Exp. Cell Res., 1, 497 (1950).
Needham, J., “Biochemistry and Morphogenesis” (Cambridge, 1942).
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BULLOUGH, W., JOHNSON, M. Epidermal Mitotic Activity and Oxygen Tension. Nature 167, 488 (1951). https://doi.org/10.1038/167488a0
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DOI: https://doi.org/10.1038/167488a0
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