Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Restitution of Plasma Sodium by the ‘Glucocorticosteroid’ Compound E in Adrenalectomized Rats

Nature volume 167, pages 322–323 (1951)Cite this article

Abstract

IN biological assays, preference is usually given to methods which reveal most specifically the differences of action of chemically related compounds. This procedure is justified whenever the aim of an experiment is the identification or quantitative estimation of different agents. However, it involves the serious risk that divergent aspects are over-emphasized and regarded as the essential features of the respective agents, whereas the points of similarity are overlooked.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Kendall, E. C., J. Amer. Med. Assoc., 116, 2394 (1941).

    Article  CAS  Google Scholar 

  2. Thorn, G. W., Engel, L. L., and Lewis, R. A., Science, 94, 348 (1941).

    Article  ADS  CAS  PubMed  Google Scholar 

  3. Verzár, F., Schweiz. med. Wschr., 80, 468 (1950).

    PubMed  Google Scholar 

  4. Verzár, F., and Wang, F. C., Amer. J. Physiol., 159, 263 (1949); Nature, 165, 114 (1950).

    PubMed  Google Scholar 

  5. Wirz, H., Helv. Physiol. Acta, 8, 186 (1950).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Physiological Laboratory, University of Basle,

    H. WIRZ

Authors
  1. H. WIRZ
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

WIRZ, H. Restitution of Plasma Sodium by the ‘Glucocorticosteroid’ Compound E in Adrenalectomized Rats. Nature 167, 322–323 (1951). https://doi.org/10.1038/167322a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/167322a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing