Abstract
THE development of populations of bacteria showing increased resistance to drugs is usually assumed to be the result of : (1) a continuous increase in resistance as a result of interaction between drug and cell1, that is, adaptation, or (2) a discontinuous increase due to selection of a few resistant cells either already present2 or induced by the drug3, that is, spontaneous or induced mutation.
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References
Hinshelwood, C. N., “Selective Toxicity and Antibiotics”, 243 (Cambridge University Press, 1948).
Oakberg, E. F., and Luria, S. E., Genetics, 32, 249 (1947).
Linz, R., Martin, L., and Lecocq, Mme. E., C.R. Soc. Biol., 143, 728 (1949).
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GIBSON, M., GIBSON, F. Development of Resistance to Dihydrostreptomycin by Bacterium coli. Nature 167, 113–114 (1951). https://doi.org/10.1038/167113b0
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DOI: https://doi.org/10.1038/167113b0
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