Abstract
SINCE the discovery of lithium aluminium hydride1, it has been used for a variety of reductions2. Its reactions are normally those of hydride anions, and in the type of compound with which it reacts there is a far-reaching analogy with the Grignard reagent. The mechanism of the reaction has been investigated by Trevoy and Brown3, who concluded from a wide range of evidence that the rate-determining step is a bimolecular nucleophilic substitution by a hydride ion, possibly complex.
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References
Finholt, Bond and Schlesinger, J. Amer. Chem. Soc., 69, 1199 (1947).
For a review, see A. W. Johnson, Ann. Rep. Chem. Soc., 46, 140 (1949).
Trevoy and Brown, J. Amer. Chem. Soc., 71, 1675 (1949).
Evans and Lee, J. Amer. Chem. Soc., 55, 1474 (1933).
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PADDOCK, N. Role of the Solvent in Reduction with Lithium Aluminium Hydride. Nature 167, 1070–1071 (1951). https://doi.org/10.1038/1671070a0
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DOI: https://doi.org/10.1038/1671070a0
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