Abstract
INSULIN has been found by many workers to increase the rate of glucose utilization of rat diaphragm muscle in vitro. It has been observed1 that if the diaphragm is given a preliminary incubation, for 30 min. or less, in a crude extract of anterior pituitary glands, the rates of glucose utilization and of glycogen synthesis in a subsequent normal incubation are unaffected by insulin. A similar system has since been used by Stadie et al.2,3, who measured glycogen synthesis only, and their results have confirmed this finding.
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References
Ottaway and Smith, Biochem. J., 43, xl (1948).
Stadie, Haugaard, Hills and Marsh, Amer. J. Med. Sci., 218, 275 (1949).
Stadie, Haugaard, Marsh and Hills, Amer. J. Med. Sci., 218, 265 (1949).
Cotes, Reid and Young, Nature, 164, 209 (1949).
Wilhelmi, Fishman and Russell, J. Biol. Chem., 176, 135 (1948).
Stadie and Zapp, J. Biol. Chem., 170, 55 (1947).
Milman and Russell, Endocrin., 47, 114 (1950).
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OTTAWAY, J. Action of Growth Hormone on Isolated Rat Diaphragm. Nature 167, 1064–1065 (1951). https://doi.org/10.1038/1671064a0
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DOI: https://doi.org/10.1038/1671064a0
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