Abstract
IN the course of an experiment on the radiobiology of the liver carcinoma of the rat induced by butter-yellow, an attempt was made to transmit the autogenous tumour by transplantation into the subcutaneous tissues of young animals of the same strain. The strain of albino rat used as hosts was not, however, sufficiently homogeneous, and a high percentage of spontaneous regressions occurred in these animals in spite of repeated passage. A group of resistant rat hosts was thus obtained in which the inoculated tumours had grown for about a fortnight, and then rapidly regressed to small, barely palpable nodules. In view of the known ability of total body radiation1 and trypan blue2 to depress the host's resistance to tumour, these animals were divided into four groups, one of which was treated with total body irradiation (central body dose: 525 r., 240 kV., HVL 1.5 mm. copper); in another, each animal was injected subcutaneously with 2 ml. of a 0.5 per cent aqueous solution of trypan blue; a third group was placed on the standard hepatoma-inducing butter-yellow diet, and a fourth group used as controls.
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COHEN, A., COHEN, L. Analogous Effects of Radiation and Trypan Blue on Rats Resistant to Transplanted Hepatoma. Nature 167, 1063 (1951). https://doi.org/10.1038/1671063a0
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DOI: https://doi.org/10.1038/1671063a0
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