Abstract
IT has often been observed that the administration to a susceptible host of an excessive infecting dose of virus may be followed by a reaction of considerably less intensity than that induced by a normal or small infecting dose1. This has been variously attributed to the presence of antibodies in the larger inoculum, or to the fact that attenuated or non-virulent particles2,3 interfere with the development of the normal particles.
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References
Beveridge, W. I. B., Proc. Roy. Soc. Med., 43, 964 (1950).
Henle, W., and Henle, G., Science, 98, 87 (1943).
von Magnus, P., Proc. 4th Int. Cong. Microbiology, 300 (1947).
Boyd, J. S. K., J. Path. Bact., 62, 501 (1950).
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BOYD, J. ‘Excessive Dose’ Phenomenon in Virus Infections. Nature 167, 1061–1062 (1951). https://doi.org/10.1038/1671061b0
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DOI: https://doi.org/10.1038/1671061b0
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