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Preparation of Bicholestatriene from Cholesterylacetate

Abstract

IN a recent communication in Nature, Hafez1 has described the isolation of a yellow bicholestatriene from the mixture of products obtained by the action of N-bromosuccinimide on Δ6-i-cholestadiene. A compound of similar, if not identical, nature is also occasionally obtained as a by-product of the preparation of 7-dehydrocholesterylacetate from cholesteryl-acetate and N-bromosuccinimide according to the procedure of Bernstein et al.2.

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References

  1. Hafez, M., Nature, 165, 401 (1950).

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  2. Bernstein, S., et al., J. Org. Chem., 14, 433 (1949).

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OTTKE, R., BERGMANN, W. Preparation of Bicholestatriene from Cholesterylacetate. Nature 166, 997–998 (1950). https://doi.org/10.1038/166997c0

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