Abstract
THE in vitro effects of hormones on animal hexokinase described by Colowick, Cori and Slein1 suggested the possibility of using the hexokinase reaction as a test system for the investigation of hormonal levels in human blood. Smith2 recently reported an unsuccessful attempt to isolate hexokinase inhibitors from fractions of diabetic plasma. In our own experiments an inhibition of hexokinase by unfractionated diabetic plasma, reversible by insulin in vivo, though not regularly in vitro, could be observed in seven out of fourteen cases investigated so far.
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References
Colowick, S. P., Cori, G. T., and Slein, M. W., J. Biol. Chem., 168, 583 (1947).
Smith, R. H., Biochem. J., 42, liii (1948).
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WEIL-MALHERBE, H. An Inhibitor of Hexokinase in the Plasma of Diabetics. Nature 165, 155 (1950). https://doi.org/10.1038/165155a0
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DOI: https://doi.org/10.1038/165155a0
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