Abstract
RECENTLY, Euler et al.1,2 have described a peculiar effect of certain normal, as well as sarcomatous, rat sera on the stainability of tumour cells. When smear preparations of mouse ascites carcinoma or rat Jensen sarcoma were incubated with the sera, a distinct loosening of the internal structure of the nuclei, demonstrated by May-Grünwald and Giemsa stains, and a total loss of Feulgen nucleal reaction, were observed. This effect was termed the ‘karyolytic effect’. It was also noticed when smear preparations of rat liver pulp were incubated with some samples of normal and sarcomatous rat sera. Human and rabbit blood serum, however, did not show the effect. No relationship appeared to exist between the effect observed in the case of certain rat sera and any known physiological, pathological or dietetic factors. Recent attempts3 to provoke ‘karyolysis’ by active immunization have not yet yielded any distinct positive results.
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v. Euler, H., Heller, L., and Curman, C., Arkiv for Kemi, 1, 299 (1949).
v. Euler, H., Heller, L., and Curman, C., Arkiv for Kemi, 1, 373 (1949).
v. Euler, H., and Heller, L., Arkiv for Kemi, 1, 425 (1949).
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GIRI, K. The Karyolytic Factor in the Serum of Rats Injected with Colchicine. Nature 165, 1021 (1950). https://doi.org/10.1038/1651021a0
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DOI: https://doi.org/10.1038/1651021a0
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