Abstract
ANALOGUES of folio acid have been found capable of inhibiting the growth of the Rous sarcoma in chickens1 and sarcoma 180 in mice2, of causing a remission in leukæmic children3 and of prolonging the survival of leukæmic mice4. The effect of twelve of these analogues (all samples of folic acid and its analogues were kindly supplied by Lederle Laboratories, Pearl River, New York) on the growth of tumours induced by the crown gall bacterium on carrot tissue has been tested. Cylinders of tissue 10 mm. diameter × 6 mm. high were removed as described in a previous communication5, and inoculated with virulent crown gall bacteria. Four days later, when the first signs of tumour formation became visible along the line of the cambium, 0.05 ml. of a 1/1,000 solution of the folic acid analogue to be tested was dropped on to, and spread over, the surface of the tissue. The amount of substance applied was 0.05 mgm. per fragment. Sterile distilled water was applied to the control group. Twenty carrot fragments were used in each test. The accompanying table shows the percentage of fragments which had developed macroscopically visible tumours four weeks after treatment had been applied.
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Little, P. A., Sampath, A., and Subbarow, Y., J. Lab. Clin. Med., 33, 1139 (1948).
Moore, A. E., Stock, C. C., Sugiura, K., and Rhoads, C. P., Proc. Soc. Exp. Biol. Med., 70, 396 (1949).
Farber, S., Diamond, L. K., Mercer, R. D., Sylvester, R. F., jun and Wolff, J. A., New England J. Med., 238, 787 (1948).
Burchenal, J. H., Burchenal, J. R., Kushida, M. N., Johnston, S. F. and Williams, B. S., Cancer, 2, 113 (1949).
de Ropp, R. S., Nature, 162, 459 (1948).
Stock, C. C., personal communication.
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DE ROPP, R. Inhibiting Action of some Analogues of Folic Acid on the Growth of Plant Tumours. Nature 164, 954 (1949). https://doi.org/10.1038/164954a0
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DOI: https://doi.org/10.1038/164954a0
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