Abstract
FROM a study of the action of ultra-violet light on monolayers of proteins, Mitchell1 suggested that tyrosine absorption leads to breakage of the —CONH— bond adjacent to the chromophore. According to Pauling and Niemann2 the C—N linkage has the lowest bond energy and should, therefore, be the first to break when energy is supplied to the molecule. Mitchell's model experiments for proteins with stearyl anilide suffer from the drawback that the phenyl group is directly adjacent to the —CONH— link, but Carpenter3 has shown that, with benzyl stearyl amine and β-phenyl ethyl stearyl amine, cleavage also occurs where the benzene ring and the —CONH— linkage are separated by one or two —CH2— groups.
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References
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MANDL, I., MCLAREN, A. Quantum Yields for Photolysis of the Peptide Bond at 2537 A.. Nature 164, 749–750 (1949). https://doi.org/10.1038/164749b0
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DOI: https://doi.org/10.1038/164749b0
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