Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Pyrophosphatase Activity of Brain Tissue

Abstract

AN enzyme capable of hydrolysing inorganic pyrophosphate was demonstrated in muscle by Lohmann1. It has also been found in various other tissues2–4 and organisms5,6, and its properties have been examined in detail in preparations obtainable from yeast7 and from erythrocytes8. The system does not, however, appear to have been demonstrated previously in brain tissue ; accordingly, it may be of interest to quote some experiments on the magnesium-activated pyrophosphatase activity of rat brain, carried out here as part of a more comprehensive investigation of brain phosphatases.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Lohmann, K., Biochem. Z., 203, 172 (1928).

    CAS  Google Scholar 

  2. Kay, H. D., Biochem. J., 22, 1446 (1928).

    Article  CAS  Google Scholar 

  3. Roche, J., Biochem. J., 25, 1724 (1931).

    Article  CAS  Google Scholar 

  4. Minniti, G., Biochim. Terap. sper., 26, 417 (1939).

    CAS  Google Scholar 

  5. Pett, L. B., and Wynne, A. M., Biochem. J., 27, 1660 (1933).

    Article  CAS  Google Scholar 

  6. Bauer, E., Hoppe-Seyl. Z., 239, 195 (1936).

    Article  CAS  Google Scholar 

  7. Bailey, K., and Webb, E. C., Biochem. J., 38, 394 (1944).

    Article  CAS  Google Scholar 

  8. Naganna, B., and Menon, V. K. N., J. Biol. Chem., 174, 501 (1948).

    CAS  PubMed  Google Scholar 

  9. Fleischhacker, H. H., J. Mental Sci., 84, 947 (1938).

    Article  CAS  Google Scholar 

  10. Fiske, C. H., and Subbarow, Y., J. Biol. Chem., 66, 375 (1925).

    CAS  Google Scholar 

  11. Giri, K. V., and Datta, N. C., Biochem. J., 30, 1089 (1936).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

GORDON, J. Pyrophosphatase Activity of Brain Tissue. Nature 164, 579–580 (1949). https://doi.org/10.1038/164579b0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/164579b0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing