Abstract
BY using the cornea of the rabbit as the site of infection it has been found possible, by a method based on that described by Robson1, to produce consistently a standard tuberculous lesion reliable enough for studying the effect of anti-tuberculous substances in vivo. In previous work2, it has been shown that drugs introduced into the posterior chamber (vitreous) of the rabbit's eye diffuse into the anterior chamber (aqueous) and cornea and maintain an adequate chemotherapeutic level over a period of at least 48–72 hours. Full details of the methods and results obtained with streptomycin and the sodium salt of p-amino-salicylic acid will be published later.* In the meantime, following the observations of Vennesland et al.3 on the in vitro additive and synergistic effect of streptomycin and p-amino-salicylic acid, the combined effect of these two drugs has been tried in vivo using this method.
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References
Robson, J. M., Brit. J. Ophthal., 28, 15 (1944).
Gardiner, P. A., Michaelson, I. C., Rees, R. J. W., and Robson, J. M., Brit. J. Ophthal., 32, 449 (1948).
Vennesland, K., Ebert, R. H., and Bloch, R. G., Proc. Soc. Exp., Biol., N.Y., 68, 250 (1948).
McClosky, W. J., Smith, M. I., and Frias, J. E. G., J. Pharmacol., 92, 447 (1948).
Levaditi, C., Girard, A., and Vaisman, A., Bull. Acad. Nat. de Med., 132, 210 (1948).
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REES, R., ROBSON, J. Additive Effect of Streptomycin and p-Amino-Salicylic Acid in Experimental Tuberculous Infection. Nature 164, 351 (1949). https://doi.org/10.1038/164351a0
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DOI: https://doi.org/10.1038/164351a0
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