Abstract
Bacon and Bell1 isolated and identified fructose in fœtal sheep's blood. This was the first conclusive proof of its existence prenatally. They also showed it disappears from the blood of the new-born lamb within three days of birth. During 1948 we performed experiments designed to throw some light on the mode of formation and site of origin of this fructose. Cæsarean section was performed under spinal anæsthetic supplemented by pentothal (which we find to be without effect on the blood sugar). The ewe was immersed in saline at 38° C. into which the fœtus was delivered. Blood samples were taken from the maternal dorsalis pedis artery and the umbilical vein. The total reducing substances and the fructose were estimated by the Somogyi–Nelson2 method and the Cole3 modification of the Roe's method respectively. The difference was taken as an approximate measure of the glucose.
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References
Bacon, J. S. D., and Bell, D. J., Biochem. J., 40, xlii (1946).
Nelson, N., J. Biol. Chem., 153, 375 (1944).
Cole, S. J., described in ref. 1.
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HUGGETT, A., WARREN, F. & WINTERTON, V. Origin and Site of Formation of Fructose in the FŒtal Sheep. Nature 164, 271 (1949). https://doi.org/10.1038/164271a0
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DOI: https://doi.org/10.1038/164271a0
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