Abstract
THE substance N,N-dibenzyl-β-chloroethylamine was synthetized by Eisleb in 1930 1. However, its very interesting biological properties were not discovered until 1945 by Nickerson and Goodman2. Since then, Nickerson and his associates have published a series of papers on this substance, which has been given the trade mark ‘Dibenamine'. The action of ‘Dibenamine’ mainly consists of an adrenergic block of higher degree and duration than that of any older drug of this type. It has already been widely used in physiological studies concerning the sympathetic nervous system. Nickerson and Goodman3 consider that ‘Dibenamine’ exerts its systemic effect after an intramolecular re-arrangement, forming a highly reactive, cyclic ethylenimonium cation. This procedure, however, takes some time, and thus explains why the substance in vivo does not develop its full effect until about thirty minutes after an intravenous injection.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
D.R.P. 538 456.
Fed. Proc., 2, 109 (1945).
Fed. Proc., 7, 397 (1948).
Fed. Proc., 5, 195 (1946).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
NYMAN, E. A Sympatholytic (Adrenergic Blocking) Substance (Dibenzyl-β-Chloroethyl Ethyl Ammonium Bromide) with Rapid Action and High Activity in Animal Experiments. Nature 164, 269–270 (1949). https://doi.org/10.1038/164269b0
Issue Date:
DOI: https://doi.org/10.1038/164269b0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
