Abstract
IN 1935, T. E. Weichselbaum1 demonstrated that rats on a diet poor in sulphur-containing amino-acids developed ‘hæmorrhages' in the liver. Four years later, Gyorgy and Goldblatt2 established that these were, in fact, areas of necrosis, and in 1945 Glynn, Himsworth and Neuberger3 showed that the factor in protein, lack of which caused such necrosis, was cystine. But since that time it has become clear that, even when similar diets are used, there are surprising discrepancies between the results obtained in different laboratories ; some investigators producing the lesion regularly, others occasionally, and some not at all4. In view of the fact that much work is being started in this field, it may be useful to make known without delay the results of a pilot experiment which seems to throw some light on these discrepancies.
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References
Weichselbaum, T. E., Quart. J. Exp. Physiol., 25, 363 (1935).
Gyorgy, P., and Goldblatt, H., J. Exp. Med., 70, 185 (1939).
Glynn, L. E., Himsworth, H. P., and Neuberger, A., Brit. J. Exp. Path., 26, 326 (1945).
Radakrishna Rao, M. V., Nature, 161, 446 (1948).
Schwartz, K., Z. physiol. Chem., 281, 101, 109 (1944).
Gyorgy, P., 6th Conf. on Liver Injury, Josiah Macy, Jr., Foundation Report, 67 (New York, 1947).
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HIMSWORTH, H., LINDAN, O. Dietetic Necrosis of the Liver : the Influence of α-Tocopherol. Nature 163, 30 (1949). https://doi.org/10.1038/163030a0
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DOI: https://doi.org/10.1038/163030a0
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