Abstract
THE occurrence of D amino-acids in several antibiotic polypeptides has stimulated interest in the correlation between the optical form of amino-acids and their effect on the antibacterial activity of certain molecules1,2. In furtherance of the investigation previously reported by Linnell and Smith3, the synthesis and resolution of the ethyl ester of DL-N. acridyl-(5)-alanine has been accomplished.
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Work, T. S., Biochem. Soc. Symposia, 1, 61 (1948).
Harris, J. I., and Work, T. S., Nature, 161, 804 (1948).
Linnell, W. H., and Smith, M. J. H., Quart. J. Pharm. Pharmacol, 21, 121 (1948).
Barber, H. J., Wilkinson, J. H., and Edwards, W. G. H., J. Soc., Chem. Ind., 66, 414 (1947).
Dupré, D. J., and Robinson, F. A., J. Chem. Soc., 549 (1945).
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LINNELL, W., SMITH, M. N. Acridyl-(5)-Alanines as Antibacterial Substances. Nature 162, 735 (1948). https://doi.org/10.1038/162735a0
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DOI: https://doi.org/10.1038/162735a0
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