Abstract
THE administration of p-dimethylaminoazobenzene to female albino rats on a rice diet has been shown to cause a cessation of the œstral cycles two weeks after administration of the carcinogenic compound1. The weight of the ovaries was reduced, and histo-logically there was an almost complete absence of corpora lutea. In male rats the weight of the testes was reduced and spermatogenesis inhibited. The weight of the adrenal was found to be smaller in the male than that in the female rats, in conformity with the findings of Hatai2. There was no effect on the weight or histological appearance of the adrenal gland in either sex ; 78 per cent of these rats developed hepatic tumours3.
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References
Hoch-Ligeti, C., Brit. J. Exp. Path., 27, 211 (1946).
Hatai, S., Anat. Rec., 8, 511 (1914).
Hoch-Ligeti, C., Cancer Res., 6, 563 (1946).
Bielschowsky, F., Brit. Med. Bull., 4, 382 (1947).
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HOCH-LIGETI, C. Effect of Feeding 2-Acetaminofluorene on the Adreno-Gonadal System of Rats. Nature 161, 58–59 (1948). https://doi.org/10.1038/161058a0
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DOI: https://doi.org/10.1038/161058a0
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