Abstract
After repeated feeding of menthol to mice, Fishman1 obtained results which on statistical examination showed an increase in β-glucuronidase in liver, spleen and kidney as compared with organs from untreated animals. Similar results were obtained in dogs fed with borneol. Since the compounds examined are known to be excreted as the glucuronides in certain species, Fishman considered β-glucuronidase to be responsible for glucuronide synthesis in vivo, and that he was measuring adaptation on the part of the enzyme in response to the presence of excess substrata. The work of other authors is not, however, compatible with the view that the function of β-glucuronidase in the body is other than hydrolytic2,3,4.
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References
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KERR, L., LEVVY, G. β-Glucuronidase and Tissue Damage. Nature 160, 463 (1947). https://doi.org/10.1038/160463b0
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DOI: https://doi.org/10.1038/160463b0
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