Abstract
Objective:
To test whether supplementary antioxidants immediately following acute ischaemic stroke will enhance antioxidant capacity and mitigate oxidative damage.
Design:
A randomised controlled trial.
Setting:
A university teaching hospital.
Subjects:
A total of 48 acute ischaemic stroke patients within 12 h of symptom onset.
Intervention:
Daily oral 800 IU (727 mg) of α-tocopherol and 500 mg of vitamin C (n=24), or no treatment (n=24) for 14 days. Treatment group and controls were matched for stroke subtype and age.
Main outcome measures:
α-Tocopherol, ascorbic acid, total antioxidant capacity (TAOC), plasma malondialdehyde (MDA) and C-reactive protein (CRP) before treatment, at day 7 and day 14 following recruitment.
Results:
In all, 14 days of vitamin supplementation significantly improved plasma α-tocopherol and ascorbic concentrations in the treatment group compared with the decrease seen in the control group (P<0.005 for difference in cumulative changes). TAOC increased significantly in the treatment group compared with controls (P<0.003). There was a significant reduction in plasma MDA concentration in the treatment group, in contrast to the increase seen in the control group (P<0.002).
Conclusion:
Supplementation with antioxidant vitamins within 12 h of onset of acute ischaemic stroke increased antioxidant capacity, reduced lipid peroxidation products and may have an anti-inflammatory effect.
Sponsorship:
Sheffield Teaching Hospital NHS Trust.
After adjusting for clinical complications CRP concentrations within 90 days postinfarct were significantly lower in the treatment group compared with controls.
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Acknowledgements
This work was supported by a Grant from Sheffield Teaching Hospital NHS Trust.
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Guarantor: SE Gariballa.
Contributors: SEG was the lead investigator and wrote the final draft of the paper and responded to the reviewers comments. Dr RU undertook subjects' recruitment and assessments and wrote the first draft of the paper. HJP was a co-investigator. All investigators were involved in the study design and analysis.
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Ullegaddi, R., Powers, H. & Gariballa, S. Antioxidant supplementation enhances antioxidant capacity and mitigates oxidative damage following acute ischaemic stroke. Eur J Clin Nutr 59, 1367–1373 (2005). https://doi.org/10.1038/sj.ejcn.1602248
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DOI: https://doi.org/10.1038/sj.ejcn.1602248
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