Abstract
The bilirubin content of the blood is increased in hæmolytic conditions, as can be demonstrated by the indirect quantitative reaction of Van den Bergh. It seems probable, therefore, that the presence in the umbilical circulation of increased bilirubin, demonstrated by the indirect reaction, might be interpreted as early diagnostic evidence of hæmolytic disease of the newborn.
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References
Yllpöa, A., Z. Kinderhlk., 9, 208 (1913).
Needham, J., "Chemical Embryology" (Cambridge University Press, 1931), 1373.
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SADOWSKI, A., BROMBERG, Y. & BRZEZINSKI, A. Determination of Bilirubin in the Umbilical Blood as an Aid in the Early Diagnosis of Hæmolytic Disease in the Newborn. Nature 160, 192 (1947). https://doi.org/10.1038/160192a0
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DOI: https://doi.org/10.1038/160192a0
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