Abstract
Objective: To study the lipoprotein distribution of supplemented coenzyme Q10 (CoQ10), vitamin E, and polyunsaturated fatty acids (PUFA).
Design: Balanced three-period crossover study.
Setting: University research unit.
Subjects: Eighteen apparently healthy free-living non-smoking volunteers (nine women, nine men), mean age 26±3 y, recruited among the university students; no dropouts.
Interventions: Three supplementation periods of 10 days: 100 mg/day CoQ10, 350 mg/day D-α-tocopherol, and 2 g/day concentrated fish oil. Fasting venous blood samples were collected twice before the first period and then after each period. Plasma and isolated lipoproteins were analysed for cholesterol, triacylglycerol, α- and γ-tocopherol, CoQ10, and fatty acid composition.
Results: Significant (P<0.05) increase in CoQ10 and α-tocopherol occurred in all lipoprotein classes after supplementation. CoQ10 was primarily incorporated into low-density lipoprotein (LDL). α-tocopherol and fish oil n-3 PUFAs had similar patterns. They were equally distributed between LDL and high-density lipoprotein (HDL), with a smaller part in VLDL. The total sum of PUFA was unchanged following all supplementations, but fish oil increased the amount of n-3 fatty acids at the expense of n-6 fatty acids.
Conclusion: Lipoprotein distribution of CoQ10 is markedly different from that of α-tocopherol, suggesting that they may be metabolised by distinct routes. α-Tocopherol is distributed similarly to n-3 fatty acids, thus providing protection on location for the oxidatively labile PUFAs.
Sponsorship: University (LMC Centre for Advanced Food Studies).
European Journal of Clinical Nutrition (2001) 55, 115–123
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Guarantor: G Hølmer.
Contributors: VH Sunesen, C Weber and G Hølmer.
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Hougaard Sunesen, V., Weber, C. & Hølmer, G. Lipophilic antioxidants and polyunsaturated fatty acids in lipoprotein classes: distribution and interaction. Eur J Clin Nutr 55, 115–123 (2001). https://doi.org/10.1038/sj.ejcn.1601127
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DOI: https://doi.org/10.1038/sj.ejcn.1601127
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