Abstract
SINCE the announcement by Peters, Stocken and Thompson1 of BAL as an antidote for lewisite, the compound finds increasing application in the treatment of poisoning due to arsenicals2, mercury salts3,4 and organic mercurials5 in humans and animals. Substances containing —SH groups are known to influence blood coagulation, for example, thiosulphate6, cysteine7,8 and glutathione9. In preliminary experiments it was observed that BAL was more active as an anticoagulant than cysteine. This made desirable a detailed study of the influence of BAL on the components of the clotting system.
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References
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FANTL, P., NANCE, M. Influence of 2,3-Dimercaptopropanol (BAL) on Blood Coagulation. Nature 159, 777–778 (1947). https://doi.org/10.1038/159777c0
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DOI: https://doi.org/10.1038/159777c0
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