Abstract
THE purpose of the experiments to be described in this paper have been: (1) to continue studies on the mechanism of the antibiotic and toxic effects of certain quinone derivatives1; and (2) to extend earlier investigations2 and to study the so-called axial gradients in a quantitative way. Planaria gonocephala was chosen as a suitable model organism for both purposes. Eleven different quinone derivatives have been tested.
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References
Hoffmann-Ostenhof, O., and Lee, W. H., Monatsh. Chem. (Vienna), 76, 180 (1946). Hoffmann-Ostenhof, O., and Biach, E., Monatsh. Chem. (in the press). Experientia (Basle) (in the press).
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Wallenfels, K., Chemie (Berlin), 58, 1 (1945).
Herzog, R. O., and Betzel, R., Hoppe-Seylers Z. physiol. Chem., 74, 221 (1911). Cf. also Clark, A. J., "The Mode of Action of Drugs on Cells" (London, 1933).
For example, Child, C. M., Protoplasma (Berlin), 5, 447 (1929).
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V. BERTALANFFY, L., HOFFMAN-OSTENHOF, O. & SCHREIER, O. A Quantitative Study of the Toxic Action of Quinones on Planaria gonocephala. Nature 158, 948–949 (1946). https://doi.org/10.1038/158948a0
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DOI: https://doi.org/10.1038/158948a0
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