Abstract
IN a previous communication in Nature1, we reported that the amount of vitamin A acid equivalent to one international unit of vitamin A (0.3 y pure crystalline vitamin A or 0.6 pure -carotene) is dependent on the method of administration. In the growth-test with A-deficient rats, using a -carotene standard in oily solution (orally) for comparison, the equivalents were as follows : (1) free vitamin A acid, dissolved in peanut oil and given orally, 1 I.U. equal to 4.0 y ; (2) sodium salt of crystalline vitamin A acid, dissolved in buffer solution (pH 10.0) and injected subcutaneously, 1 I.U. equal to 0.6 y.
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Nature, 157, 190 (1946).
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VAN DORP, D., ARENS, J. Biological Activity of Vitamin A Acid. Nature 158, 60 (1946). https://doi.org/10.1038/158060a0
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DOI: https://doi.org/10.1038/158060a0
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