Abstract
IT is generally agreed that infections with T. cruzi do not respond to those chemotherapeutic agents which have been recognized as effective against trypanosomes of the T. brucei class. The only drug which so far is stated to influence this South American trypanosome is the 4: 6 diamino-quinaldine derivative known as Bayer 7602 (Ac). A number of phenanthridine compounds prepared by one of us (L. P. W.1) have been investigated for action on a strain of T. cruzi (for which we are indebted to Imperial Chemical Industries, Ltd., Manchester, which also put at our disposal a specimen of the acetate of the compound consisting of two 2-methyl-4-aminoquinoline groups joined in position 6 by a diallylmalonyl group, which, according to Fulton2, corresponds in its action to Bayer 7602).
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References
Walls, L. P., Brit. Prov. Spec. Nos. 14478/43, 52/44 and 53/44.
Fulton, J. D., Ann. Trop. Med., 37, 164 (1943).
Browning, C. H., and Calver, K. M., J. Path. Bact., 55, 393 (1943)
Calver, K. M., Trop. Dis. Bull., 42, 704 (1945).
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BROWNING, C., CALVER, K., LECKIE, M. et al. Phenanthridine Compounds as Chemotherapeutic Agents in Experimental T. cruzi Infections. Nature 157, 263–264 (1946). https://doi.org/10.1038/157263b0
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DOI: https://doi.org/10.1038/157263b0
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