Abstract
IN a recent speculation Gulland and Farrar1 have elaborated a hypothesis for the mode of action of cyclotelluro-pentane-3:5-dione and homologues, in which substrate competition with pyridoxin is postulated as a possible explanation of their high bactericidal activity. The structural resemblance of these tellurium compounds to that of pyridoxin is pointed out, and it is suggested that analogous substances containing an oxygen or a sulphur atom instead of tellurium might possess correspondingly high bacteriostatic or bactericidal activity without the extreme toxicity of the tellurium compounds.
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References
Gulland and Farrar, Nature, 154, 88 (1944).
Avison et al., Nature, 154, 549 (1944).
Morgan et al., J. Chem. Soc., 117, 1464 (1929).
Morgan et al., Biochem. J., 18, 196 (1924).
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BERGEL, F., MORRISON, A., MOSS, A. et al. Antibacterial Activity of 2:6-Dimethyl-Penthiane-3:5-Dione. Nature 155, 481 (1945). https://doi.org/10.1038/155481b0
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DOI: https://doi.org/10.1038/155481b0
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