Abstract
IT has been known for some time that, following fractures, there are losses of nitrogen in the urine as urea1. Lately, in this laboratory, similar losses have been found after severe burns in animals, the loss being quite appreciable even ten days after burning2; these changes also occur in patients3. The nitrogen loss in rats can be largely eliminated by increase of protein in the diet from 14 to 22 per cent4; this figure including some 4 per cent of yeast protein4, the remainder being casein. In man it has proved necessary in some patients to give up to 2,000 gm. of protein per week to stem the nitrogen loss3.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Cuthbertson, D. C., Biochem. J., 24, 1244 (1930); for review, see Lancet, i, 433 (1942).
Clark, E. J., Peters, R. A., and Rossiter, R. J., Report to Med. Res. Council (1943) and Quart. J. Exp. Physiol. (in the press).
Taylor, F. H. L., Levenson, S. M., Davidson, C. S., Browder, N. C., and Lund, C. C., Ann. Surg., 118, 215 (1943).
Croft, P. B., and Peters, R. A., Report to Med. Res. Council (1944) and Lancet (in the press).
Wilson, W. C., unpublished reports to War Office and Med. Res. Council (1942). Wells, D. B., et al., New Engl. J. Med., 226, 629 (1942). Erb, I. H., Morgan, E. M., and Farrer, A. W., Ann. Surg., 117, 234 (1943).
Cameron, G. R., Milton, M., and Allen, J. W., Lancet, ii, 179 (1943). Barnes, J. M., and Rossiter, R. J., Lancet, ii, 218 (1943). Hartman, F. W., and Romence, H. L., Ann. Surg., 118, 402 (1943).
Colebrook et al., Med. Res. Council Special Report, No. 249 (1944). Cameron, G. R., et al., J. Path. Bad., in the press.
For reviews, see Best, C. H., and Lucas, C. C., "Vitamins and Hormones", vol. 1 (New York, 1943); McHenry, E. M., and Patterson, J. M., "Physiol Reviews" (1943); also Channon, Manifold, M. C., and Platt, A. P., Biochem. J., 34, 866 (1940).
Peters, R. A., Thompson, R. H. S., King, A. J., Williams, D. I., Nicol, C. S., Greenwood, M., and Martin, W. S., Nature, 153, 773 (1944) and Quart. J. Med., in the press.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CROFT, P., PETERS, R. Effect of Methionine upon Nitrogen Losses in the Urine following Severe Burns. Nature 155, 175–176 (1945). https://doi.org/10.1038/155175b0
Issue Date:
DOI: https://doi.org/10.1038/155175b0
This article is cited by
-
Nierenst�rungen bei der Verbrennungskrankheit
Langenbecks Archiv f�r Klinische Chirurgie (1955)
-
Protein deficiency in man
American Journal of Digestive Diseases (1946)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
