Abstract
IN the course of an investigation on the action of enzyme inhibitors on pituitary-induced ovulation of the frog's ovary (Rana pipiens) in vitro, it was found that sodium fluoride would potentiate the pituitary effect. This unexpected result was considered as possibly associated with the binding of calcium by fluoride. Accordingly, the effect of other experimental procedures such as the use of calcium-free Ringer, oxalate, change in pH, etc., was investigated. A summary of the results together with probability values is shown in the accompanying table.
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References
McPhail, M. K., and Wilbur, K. M., J. Pharmacol, and Exp. Therap., 78, 304 (1943).
Chambers, R., Cold Spring Harbor Sympos., 8, 144 (1940).
See chapter by Cohen, P. P., "Respiratory Enzymes" (Minneapolis, 1939).
Runnström, J., and Hemberg, T., Naturwiss., 25, 74 (1937).
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WILBUR, K., MCPHAIL, M. Production of Ovulation by Fluoride in vitro. Nature 154, 83–84 (1944). https://doi.org/10.1038/154083b0
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DOI: https://doi.org/10.1038/154083b0
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