Abstract
IN 1936, Windaus1 and his co-workers isolated from the irradiation products of 7-dehydrocholesterol a dinitrobenzoate identical with the ester prepared almost simultaneously by Brockmann2 from a concentrate of tunny fish-liver oil. The hydrolysates of these esters, though yielding no crystalline alcohol, clearly consisted of vitamin D3 approaching purity. The crystalline vitamin itself was first prepared by Schenk3 in 1937 from the irradiation products of 7-dehydrocholesterol. This isolation was described more fully by Windaus, Deppe and Wunderlich4 in the same year. The same crystalline vitamin was prepared5 in the following year from fish-liver oil.
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References
Windaus, A., et al., Z. physiol. Chem., 241, 100 (1939).
Brockmann, H., Z. Physiol. Chem., 241, 104 (1936).
Schenk, F., Naturwiss., 25, 159 (1937).
Windaus, A., Deppe, M., and Wunderlich, W., Ann., 533, 118 (1937).
Brockmann, H., and Büsse, A., Z. physiol. Chem., 256, 252 (1938).
Coward, K. H., Bull. Health Org. League of Nations, 9, 425 (1940–41).
Morris, N., and Stevenson, M. M., Lancet, 237, 876 (1939).
Himsworth, H. P., and Maizals, M., Lancet, 238, 959 (1940).
Wilson, D. C., Lancet, 238, 961 (1940).
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SMITH, E., GLYNN, H., WILKINSON, P. et al. Supplies of Crystalline Vitamin D3. Nature 152, 385 (1943). https://doi.org/10.1038/152385a0
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DOI: https://doi.org/10.1038/152385a0
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