Abstract
JOHNE'S disease chiefly affects the bovine. It is J a chronic bacterial enteritis caused by Myco-bacterium johnei which produces proliferative changes in, and a rather characteristic thickening of, the intestinal mucosa. The bacteria are usually confined to the intestine and adjacent lymphatic glands. Animals acquire the infection when very young, but the incubation period is protracted, symptoms usually, not occurring until two to three years of age or even later; calving or other stresses may cause the onset of symptoms. Clinical recovery may occur, but usually the diarrhoea and emaciation are progressive, eventually resulting in death.
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FRANCIS, J. INFECTION OF LABORATORY ANIMALS WITH JOHNE'S DISEASE AND LEPROSY. Nature 152, 250–251 (1943). https://doi.org/10.1038/152250a0
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DOI: https://doi.org/10.1038/152250a0
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